Evaluation of phenolic acids of Corylus avellana L. as potential SARS CoV-2 Main protease inhibitors

The novel human coronavirus, called SARS-CoV-2, first appeared in late 2019 Wuhan, causing a respiratory disease termed COVID-19 China and has been declared pandemic worldwide. Although many different vaccine development studies against SARS-CoV-2 have reached the final stage, protection that these vaccines will provide to society is not known for now, therefore, effective antiviral drugs should be developed. In this study, effects of phenolic acids found Corylus avellana L. on Main protease (Mpro) was investigated by molecular docking analysis. Also, pharmacophore properties, biological pharmacokinetics drug-likeness properties compounds examined study were evaluated. Molecular Mpro done with Autodock Vina. Many interacted active site catalytic residues Mpro. Drug similarity interacting MPro each potential target inhibitors it determined its use would limited or no side effect body.